New research suggests that drugs commonly used for heartburn, acid reflux, and ulcers may raise the risk of numerous fatal conditions, including heart disease and stomach cancer. Physicians often prescribe proton pump inhibitors(PPIs) to treat gastrointestinal conditions that involve an excess of acid production. Nexium, Aciphex, Zegerid, Dexilant, Prevacid, Prilosec, and Protonix are only some of the brand names that PPIs have taken over the years.
More than 15 million people in the United States take prescription PPIs, according to the most recent statistics available, and even more may be taking over-the-counter PPIs. A new study, appearing in the journal The BMJ, suggests that these drugs may increase the risk of death from various chronic health conditions.
Dr. Ziyad Al-Aly, an assistant professor of medicine at the Washington University School of Medicine in St. Louis, MO, is the senior investigator of the study. For the new study, Dr. Al-Aly and colleagues examined data from the medical records of the U.S. Department of Veterans Affairs.
The researchers looked at data available from mid-2002 to mid-2004, a period during which 157,625 people in the cohort received PPI prescriptions from their physicians and 56,842 people received H2 blockers, another kind of acid suppressant.
The scientists clinically followed the participants — who were predominantly male, Caucasian, and 65 years old or older — for up to a decade. They used the data to build a statistical model of a clinical trial, which would see the participants randomly assigned to take either PPI or H2 blockers. This allowed them to estimate that during the follow-up period, there would be 45.2 excess deaths per every 1,000 individuals taking PPIs.
Honing in on the causes of death, the findings revealed associations with cardiovascular disease, stomach cancer, and chronic kidney disease. The model estimates the death rates for cardiovascular disease to be 88.7 per 1,000 people in the PPI group and 73.3 per 1,000 people in the H2 blocker group.
The scientists saw 4.3 deaths in every 1,000 people from stomach cancer in the PPI group, with 4.6 deaths from the disease in the H2 blocker group in their model. The rates for chronic kidney disease deaths were 8.6 per 1,000 people in the PPI group and 4.4 in the H2 blocker group. Also, the risk of death increased with the duration of the treatment, even when the study participants had taken low doses of the drug.
Finally, the research revealed that over half of those taking PPIs had no medical need for them. "Most alarming to me is that serious harm may be experienced by people who are on PPIs but may not need them," comments Dr. Al-Aly. "Overuse is not devoid of harm."
My Take: This was a long article, so I’ll keep it short. The last paragraph says it all. When our elderly population moves into retirement communities. Typically, a medication review is performed. PPIs, antidepressants, and sleep aids are the first medications to be discontinued as unnecessary and harmful.
Bottom Line: PPI use should be limited to two weeks as the research recommends. Continued use has long been associated with anemia, malnutrition and osteoporosis. Now you can add fatal diseases like heart disease and stomach cancer to that list.
Source: June 4, 2019 NIH